The P-Shot Therapy:
P-Shot Therapy at Dot Clinics is a cutting-edge, non-surgical treatment designed to enhance male sexual health and performance by using the body’s own natural healing power.
The P-Shot (Priapus Shot®) is a form of platelet-rich plasma (PRP) therapy in which a patient’s own blood is processed to concentrate growth factors and then injected into penile tissue with the aim of improving erectile function, sensitivity, and sometimes girth. It’s minimally invasive and increasingly offered at urology clinics and medspas — but the scientific evidence is still emerging, and results are variable. Cleveland Clinic+1
1. What is the P-Shot?
The P-Shot (short for “Priapus Shot”) is a branded PRP-based procedure developed for men’s sexual health. The technique takes a small sample of the patient’s blood, spins it in a centrifuge to create platelet-rich plasma — a serum concentrated with platelets and growth factors — and then injects that plasma into specific locations in the penis (for example, the shaft and glans). The theoretical goal is to stimulate local tissue repair, improve microcirculation, and promote regenerative changes that might improve erectile function, sensation, and tissue quality. Healthline+1
2. The science behind PRP: why might it help?
Platelets release growth factors (VEGF, PDGF, TGF-β, and others) that influence angiogenesis (new blood vessel growth), reduce inflammation, and promote tissue repair. PRP’s regenerative effects are well documented in orthopedics, dermatology, and wound healing; that is the rationale for exploring PRP in penile tissue where blood flow, nerve health, and tissue integrity are central to erectile function. In animal models and small human trials, intracavernosal PRP has shown signals of improved erectile parameters — but translating those findings into robust, reproducible clinical benefits remains a work in progress. PMC+1
3. How the P-Shot procedure is performed (step-by-step)
Consultation and screening. A physician evaluates medical history, medications (especially blood thinners), causes of erectile dysfunction (ED), and expectations. Some clinics perform baseline erectile questionnaires (IIEF) or penile Doppler ultrasonography.
Blood draw. A small amount of blood (typically 15–60 mL depending on the protocol) is taken from the arm.
Centrifugation. The blood is processed in a centrifuge to separate PRP from red blood cells and platelet-poor plasma. Different systems produce PRP of varying platelet concentrations.
Preparation of the penis. The penis is cleaned and often numbed with local anesthetic.
Injection. The PRP is injected into targeted areas — commonly the corpora cavernosa (erectile bodies) and sometimes the glans — using small needles. Some providers combine PRP with other therapies (e.g., shockwave therapy, microneedling, or traction devices).
Short observation. Patients are monitored briefly for immediate reactions, then discharged with aftercare instructions (e.g., avoid vigorous sexual activity for a set period). Comprehensive Urology+1
4. Typical claims and realistic outcome expectations
Clinics and marketing materials often claim improvements such as:
Stronger erections, improved rigidity
Increased penile sensitivity and enhanced sexual pleasure
Better control over ejaculation (in some anecdotal reports)
Mild increases in girth or length (controversial and not well proven)
Improved response to PDE-5 inhibitors (Viagra, Cialis) in some men
Reality check: while individual patients sometimes report improvements, high-quality, large randomized controlled trials are limited. Some small clinical studies report short-term improvements in erectile scores; systematic reviews describe promising signals but caution that the evidence is preliminary and heterogeneous (different PRP systems, protocols, outcome measures). Therefore, the P-Shot may help some men, particularly with early or mild organic causes of ED, but it is not a guaranteed or universally effective cure. PubMed+1
5. Evidence summary — what the studies say
Small trials and case series: Several small single-center trials and case reports suggest PRP is safe and can produce short-term improvements in erectile function scores in some patients. PubMed
Systematic reviews: Reviews of the literature conclude that while preliminary results are encouraging, studies are small, often non-randomized, use different preparation and injection methods, and have short follow-up. Authors call for larger, standardized randomized controlled trials before routine endorsement. Oxford Academic+1
Clinical consensus/guidelines: Major urology guideline documents (for example, the American Urological Association’s ED guidance) do not currently endorse PRP/P-Shot as a first-line treatment and highlight the need for higher-quality evidence. Providers are urged to discuss uncertainty and alternatives with patients. American Urological Association+1
6. Who may be a good candidate — and who should avoid it?
Potential candidates:
Men with mild-to-moderate erectile dysfunction who prefer regenerative/minimally invasive options.
Men who cannot tolerate or prefer to avoid daily oral ED medications.
Those willing to accept uncertain outcomes and the cost.
Not ideal candidates:
Men with severe vascular disease, advanced diabetes with neuropathy, or untreated hormonal issues may respond poorly.
Anyone on anticoagulant therapy or with bleeding disorders — PRP involves injections and a blood draw, so bleeding risk must be accounted for.
Men expecting guaranteed size increases or miraculous results; marketing overpromises are common. Always discuss realistic goals. Cleveland Clinic+1
7. Safety and side effects
Because PRP uses the patient’s own blood, allergic reactions are exceedingly rare. However, injection procedures carry risks:
Common/minor: Pain at injection site, bruising, swelling, temporary discoloration, transient numbness. These often resolve in days. ahdubai.com
Less common/serious: Infection at the injection site (rare), hematoma formation, nerve irritation, or scarring. Improper injection technique could theoretically damage penile structures.
Unknown long-term risks: Long-term safety data are limited; therefore, use should be conservative and performed by trained medical professionals. Clinics should maintain sterile technique and use validated PRP systems. PMC+1
8. Practical considerations: cost, sessions, downtime
Cost: Widely variable. Many clinics charge several hundred to several thousand dollars per session depending on location, reputation, technology used, and whether additional therapies are bundled. Typical ranges often cited: a few hundred to a few thousand USD/Euro per session. Insurance usually does not cover the P-Shot since it is often considered experimental or elective. Safe Urology Clinic+1
Number of sessions: Protocols differ. Some providers recommend a single treatment with maintenance every 6–12 months; others suggest a series (e.g., 1–3 sessions spaced a few weeks apart) for more lasting effect. Evidence is not standardized. Castillo, Peter (swanmd.com)+1
Downtime: Minimal. Many men return to normal daily activities within 24–48 hours and are typically advised to avoid sexual activity for 48 hours or as instructed. Strenuous exercise should be avoided briefly to reduce swelling or bruising. ahdubai.com
9. Combining the P-Shot with other therapies
Some clinics combine PRP with adjunctive treatments to try to boost outcomes:
Low-intensity shockwave therapy (LI-ESWT): Shockwave promotes angiogenesis; early studies suggest combined PRP + shockwave may be synergistic, but evidence is still limited.
PDE-5 inhibitors (sildenafil/tadalafil): Some men report better responses to oral medications after PRP.
Vacuum erection devices or traction: Mechanical approaches can be used as part of a comprehensive rehabilitation plan.
Combining therapies increases cost and complexity; ensure combinations are backed by a clear rationale and discussed with a urologist. auanews.net+1
10. Red flags & questions to ask a provider
Before you get a P-Shot, ask your provider:
Are you a licensed physician with experience in male sexual medicine? How many P-Shot procedures have you performed?
Which PRP system do you use and what is the platelet concentration? Is that data available?
Are there independent outcome data or before/after validated questionnaires (IIEF) you can share (not just marketing images)?
What specific results can I reasonably expect, and what is your refund/maintenance policy if I don’t see improvement?
What are the costs (procedure, consumables, follow-ups) and is there a written consent form detailing risks?
Do you screen for underlying causes of ED (cardiovascular disease, diabetes, low testosterone) and discuss alternative evidence-based treatments?
If a clinic overpromises or pressures you into a package without clear answers, treat it as a warning sign. Cleveland Clinic+1
11. Alternatives to the P-Shot (evidence-based options)
If your goal is improved erections, several well-studied treatments exist:
Oral medications (PDE-5 inhibitors): Widely effective for many men with vascular ED.
Counseling/sex therapy: For psychogenic or mixed causes of ED.
Testosterone replacement: If low testosterone is clinically demonstrated.
Vacuum erection devices, penile injection therapy (alprostadil), intraurethral suppositories.
Penile prosthesis: A surgical option with high satisfaction rates for refractory cases.
Discuss with a urologist which option or combination best fits your medical profile and goals. Guideline recommendations still prioritize established therapies while considering regenerative options as experimental pending stronger evidence. American Urological Association
12. Frequently asked questions (short)
Q: Is the P-Shot painful? A: Providers usually use local anesthetic; most men feel pressure or mild discomfort but not severe pain. Mild soreness afterward is common. ahdubai.com
Q: How soon will I see results? A: Some men report improvement within weeks, others need months, and some notice no benefit. Reported durations of benefit vary; some clinics say effects can last 6–12 months. Evidence is inconsistent. evolvecedarvalley.com
Q: Will insurance pay for it? A: Usually not — the P-Shot is often considered elective or investigational. Verify with your insurer. Safe Urology Clinic
Q: Can PRP increase penis size permanently? A: There’s no strong scientific proof that PRP reliably increases length or girth in a permanent, measurable way. Claims of size increase should be treated skeptically. Cleveland Clinic
13. Bottom line — should you consider it?
The P-Shot is an intriguing regenerative option with a logical biological rationale and encouraging early results in small studies and anecdotal reports. However, high-quality evidence (large randomized controlled trials with standardized PRP protocols and long-term follow-up) is still lacking. If you’re curious about the P-Shot:
Seek evaluation by a qualified urologist experienced in male sexual medicine.
Make sure a full medical workup for ED is completed (cardiovascular risk factors, diabetes, hormonal testing).
Understand costs, the experimental nature of the treatment, and realistic outcomes.
Consider evidence-based alternatives first when appropriate, or use PRP as part of a combined, well-explained plan.
In short: P-Shot may help some men, but it is not yet a proven, first-line standard of care. Discuss benefits, uncertainties, and risks in a shared decision with your clinician. Oxford Academic+1
14. Selected references & further reading
Cleveland Clinic — overview of the P-Shot and evidence commentary. Cleveland Clinic
Systematic reviews and reviews on PRP for erectile dysfunction (PMC and academic reviews). PMC+1
Small clinical trials reporting short-term improvements with intracavernosal PRP. PubMed+1
American Urological Association erectile dysfunction guideline (for comparison to established treatments). American Urological Association
Last updated